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KMID : 0614619930250020337
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Korean Journal of Gastroenterology
1993 Volume.25 No. 2 p.337 ~ p.344
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Serum Type IV Collagen Levels in Various Liver Diseases
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정진이
한광협/박영년/전재윤/문영명/강진경/박인서/최홍재/박찬일
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Abstract
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Serum type IV collagen levels determined with one-step sandwich enzyme immunoassay using monoclonal antibodies were compared with histologic changes in the liver biopsy specimens from 95 patients with various liver diseases. Although serum type
IV
collagen levels were not significantly increased in patients with fatty liver and chronic persistent hepatitis compared to normal controls, serum type IV collagen levels were significantly increased in patients with chronic liver disease such as
chronic
active hepatitis or liver cirrhosis compared to normal controls and patients with fatty liver and chronic persistent hepatitis. According to the progression of liver disease, serum type IV collagen levels were significantly increased. In
addition,
all
the 31 patients with chronic active hepatitis with early cirrhosis and liver cirrhosis showed elevated serum type IV collagen levels higher than mean plus one standard deviation level of controls. Serum type IV collagen levels did not correlate
with
serum transaminase levels in patients with chronic liver disease. A significant positive correlation was found between the serum type IV collagen level and the degree of fibrosis, piecemeal necrosis and portal and/or periportal inflammation in
patients
with chronic active hepatitis.
The results suggest that the serum type IV collagen levels correlate well with the degree of hepatic fibrosis. Therefore the measurement of serum type IV collagen level is relatively simple and useful method to reflect the progress of hepatic
fibrosis.
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KEYWORD
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